Method of modulating membrane potential of a cell

摘要

Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and/or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

主权项

1. A method of modulating membrane potential of a cell membrane comprising:
forming a synthetic chloride ion channel in the cell membrane; wherein the synthetic ion channel is formed by a plurality of molecules of a self-assembling compound having formula: wherein D is CH(R) wherein R is: (1) C1-6 alkyl optionally substituted with NH2; (2) (C1-6 alkyl)C(═O)(OC1-6 alkyl); (3) (C1-6 alkyl)S(C1-6 alkyl); (4) (C0-6 alkyl)phenyl; or (5) indolyl; X is C1-20 alkyl; and k is 1.