| 摘要 |
Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device. |
| 主权项 |
1. An isolated antibody or a binding fragment thereof, which specifically binds to both aripiprazole and dehydroaripiprazole and which is generated in response to a conjugate of a compound of Formula I and an immunogenic carrier, wherein: R1 is H,CH2NH2 or CH2NHC(O)(CH2)mCO2H;
R2 is H,NH2, or NHC(O)(CH2)mCO2H;
R3 is H; provided that either R1 or R2 must be H, and further provided that R1 and R2 must not be H simultaneously; m is 1, 2, 3, 4, or 5; and n is 1, 2, 3, 4, or 5; wherein the isolated antibody does not bind to olanzapine, quetiapine and risperidone. |
