Peptides that bind to amino-truncated amyloid-beta-peptide and use of said peptides

摘要

Peptides that bind to amino-terminal truncated pEAβ3-42, the free glutamic acid residue of which lies in position 3 or 11 in the form of cyclized pyroglutamate. Four oligopeptides were identified using mirror image phage display technology.

主权项

1. A D-enantiomeric peptide, comprising a sequence selected from the group consisting of: SEQ ID NO:1, 2, 3, 4 and a mixture thereof:
wherein said D-enantiomeric peptide, at a sequence portion consisting of one of said SEQ ID NO: 1, 2, 3, and 4 binds to amino-terminal truncated amyloid-beta peptide; and wherein said amino-terminal truncated amyloid-beta peptide is a species of amino-terminal truncated amyloid-beta peptide having a free glutamic acid residue in position 3 in the form of cyclized pyroglutamate.