Erythropoeitin production by electrical stimulation

摘要

Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patients hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patients cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.

主权项

1. A method of treating anemia in a human patient, the method comprising:
monitoring a hemoglobin level of the patient on a periodic basis; determining an anemic condition based on the hemoglobin level; determining one or more characteristics of the anemic condition; selecting electrical stimulation parameters of a neurostimulation device based on the one or more characteristics of the anemic condition; generating one or more stimulation signals to stimulate the patient's nervous system using the selected electrical stimulation parameters; monitoring at least one of an autonomic balance or an inflammatory state of the patient resulting from the neurostimulation using the selected electrical stimulation parameters; monitoring the patient's cardiac activity resulting from the neurostimulation using the selected electrical stimulation parameters; and adapting the stimulation parameters of the neurostimulation device based on at least the patient's cardiac activity.