| 发明名称 | Serologic correlates of protection against <i>bacillus anthracis </i>infection | ||
| 摘要 | Regions of Bacillus anthracis protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to Bacillus anthracis infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity. | ||
| 申请公布号 | US9610338(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201514669580 | 申请日期 | 2015.03.26 |
| 申请人 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 发明人 | Semenova Vera A.;Quinn Conrad P.;Pohl Jan;Svoboda Pavel |
| 分类号 | A61K39/02;A61K39/07;C07K14/32;G01N33/569 | 主分类号 | A61K39/02 |
| 代理机构 | Dinsmore & Shohl LLP | 代理人 | Dinsmore & Shohl LLP |
| 主权项 | 1. A Bacillus anthracis vaccine comprising an isolated immunogen consisting of 10 to 30 amino acids in the sequence of at least one of the amino acid regions 181-210, 201-230, 221-250, 241-270, 321-350, 341-370, 361-390, 421-450, 561-590, or 581-610 of SEQ ID NO: 1, or a combination thereof. | ||
| 地址 | Washington DC US | ||