Manufacture of tablet in a die utilizing powder blend containing water-containing material

摘要

The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.

主权项

1. A process for making a tablet comprising compacting the particles of a powder blend in a die platen to form a tablet shape, wherein said powder blend comprises a pharmaceutically active agent and a water-containing material having a dehydration temperature, and applying radiofrequency energy to said tablet shape within a die platen for a sufficient period of time to heat the water-containing material within said tablet shape above said dehydration temperature to form said tablet, wherein said process comprises the steps of:
(i) introducing said powder blend into a forming cavity within said die platen; (ii) compacting said particles of said powder blend by introducing at least one forming tool into said die platen with sufficient force such that a tablet shape is formed; (iii) applying said radiofrequency energy to said tablet shape within said forming cavity to bind said particles in said tablet shape to form said tablet; and (iv) removing said tablet from said forming cavity.