Imidazo bicyclic iminium compounds as antitumor agents

摘要

Compounds of formula I:;
are disclosed. The compounds are inhibitors of Hedgehog pathway activation and are useful in treating solid tumors. An example of such a compound is:
;

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula II: wherein: R1 is chosen from optionally substituted aryl and optionally substituted heteroaryl; R2a is chosen from H and (C1-C4)alkyl; R3a is chosen from optionally substituted aryl and optionally substituted heteroaryl; A1 is (a) a fused, saturated ring of 7 members that contains no heteroatoms other than the nitrogen at the point of fusion, said saturated ring optionally substituted with one or two (C1-C4)alkyl residues or
(b) a fused bicycle, one ring of said fused bicycle being a saturated ring of 7 members that contains no heteroatoms other than the nitrogen at the point of fusion and a second ring of said fused bicycle being a benzene ring, said bicycle optionally substituted with one or two (C1-C4)alkyl residues; and X is any counterion.