Molecule mixture comprising an amphipathic molecule type A, which has a positive total charge in the hydrophilic range, and an amphipathic molecule type B and A polyphenol C, method for producing said molecule mixture and use thereof

摘要

A molecule mixture comprising an amphipathic molecule of type A, which has an overall positive charge in the hydrophilic region, an amphipathic molecule of type B and a polyphenol C, the method for producing the molecule mixture, and the use thereof. The molecules of types A and B are present at a molecular ratio of A:B of 1(±0.2):1(±0.2) mol/mol. A method for producing the mixture and the use is also disclosed.

主权项

1. A liposome for delivery of an antioxidant to a cell comprising a molecule mixture comprising (A) a first amphipathic molecule, which has an overall positive charge in the hydrophilic region, (B) a second amphipathic molecule, which is neutral in the hydrophilic region, and (C) a polyphenol selected from resveratrol, curcumin, hydroxyflavone, genistein, or a mixture thereof,
wherein the molecules (A), (B) and (C) are present at a molecular ratio (A):(B):(C) of 1(±0.2):1(±0.2):1.25.-2.50 mol/mol, the liposome having a membrane and a portion interior to the membrane, and wherein a majority portion of the polyphenol (C) is within the membrane and a smaller portion than the majority portion is within the liposome interior portion.