| 发明名称 | Method for inhibiting euPTX3 to treat nasopharyngeal carcinoma by amino acid sequence | ||
| 摘要 | The invention relates to a method for inhibiting euPTX3 to treat nasopharyngeal carcinoma by an amino acid sequence, comprising administering an effective amount of the amino acid sequence to a subject in need. The amino acid sequence can be used to inhibit euPTX3 from promoting the migration and invasion of nasopharyngeal carcinoma cells, promoting angiogenesis and inhibiting macrophage phagocytosis to further treat nasopharyngeal carcinoma. | ||
| 申请公布号 | US9610325(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201414505661 | 申请日期 | 2014.10.03 |
| 申请人 | NATIONAL CHENG KUNG UNIVERSITY | 发明人 | Wang Ju-Ming;Hsiao Yu-Wei;Chi Jhih-Ying;Wang Shao-Ming |
| 分类号 | A61K38/00;A61P35/00;A61K38/16;C07K1/00;C07K14/00;C07K17/00;A61K38/17;C07K14/71 | 主分类号 | A61K38/00 |
| 代理机构 | CKC & Partners Co., Ltd. | 代理人 | CKC & Partners Co., Ltd. |
| 主权项 | 1. A method for inhibiting eukaryotic long pentraxin protein (“euPTX3”) to treat nasopharyngeal carcinoma, comprising administering an effective amount of an amino acid sequence expressed by a prokaryotic system to a subject in need thereof, wherein the amino acid sequence comprises the amino acid residues 180-381 of SEQ ID NO: 1, and wherein the amino acid sequence inhibits the migration and invasion of nasopharyngeal carcinoma cells, inhibits angiogenesis, and promotes macrophage phagocytosis. | ||
| 地址 | Tainan TW | ||