Anti-fatigue agent

摘要

Anti-fatigue agents containing dioxabicyclo[3.3.0]octane derivatives such as sesamin which is an ingredient contained in sesame, as well as pharmaceutical compositions and physiologically functional foods that contain such anti-fatigue agents are disclosed. These compounds can safely be administered to humans and animals alike and hence allow for continued ingestion while proving effective in promoting an improvement of stamina, an increase of body strength, a relief of fatigue, and recovery from fatigue.

主权项

1. A method for treating a fatigue in a subject comprising administering to the subject at least one dioxabicyclo[3.3.0]octane derivative that is represented by the following general formula (I) where R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, an alkyl group having 1-3 carbon atoms, or R1 and R2 and/or R4 and R5, when taken together, represent a methylene group or an ethylene group, and n, m, and l represent 0 or 1, to treat the fatigue in the subject,
wherein the fatigue is mental fatigue, andwherein the dioxabicyclo[3.3.0]octane derivative is sesamin and/or episesamin, andwherein the dioxabicyclo[3.3.0]octane derivative is administered to said subject in an amount corresponding to 50 to 80 mg/kg in mice.