Anti-plasmodium parasite antibodies

摘要

The technology provided herein relates to novel human antibodies against Plasmodium parasites, in particular against the malaria parasite Plasmodium falciparum. The present disclosure pertains to antibodies against merozoite surface protein 10 (MSP10). These antibodies have high affinity e.g. to Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.

主权项

1. An isolated monoclonal human antibody, or antigen-binding portion thereof, that binds specific to the first epidermal growth factor-like domain of MSP-10 (SEQ ID NO: 13) of Plasmodium falciparum, wherein said antibody or antigen-binding portion thereof inhibits the invasion of a Plasmodium falciparum parasite into the erythrocyte and/or the growth of the Plasmodium falciparum parasite within the erythrocyte by at least 50%, wherein the antibody or the antigen-binding portion thereof has a light chain variable region (LCVR) and a heavy chain variable region (HCVR), and wherein the LCVR comprises the CDR sequences of SEQ ID NOs 1, 2 and 3 and the HCVR comprises the CDR sequences of SEQ ID NOs 4, 5 and 6.