发明名称 HYDROXYPROPYL METHYL CELLULOSE HARD CAPSULES AND PROCESS OF MANUFACTURE
摘要 A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.
申请公布号 US2017087092(A1) 申请公布日期 2017.03.30
申请号 US201615378856 申请日期 2016.12.14
申请人 Capsugel Belgium NV 发明人 Cade Dominique Nicolas;Xiongwei David He
分类号 A61K9/48;A61J3/07 主分类号 A61K9/48
代理机构 代理人
主权项 1. A process comprising: forming hydroxypropyl methyl cellulose hard capsules using thermogelation by: (a) providing an aqueous composition of a 2906 hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), a hydroxypropoxy content of 4.0-7.5% (w/w) and a viscosity of 3.5-6.0 cPs as a 2% weight solution in water at 20° C., wherein the aqueous composition is substantially free of gelling agent; (b) dipping heated dipping pins into the aqueous composition, wherein the aqueous composition is maintained at a temperature below a gelling temperature of the aqueous composition, (c) withdrawing the dipping pins from the aqueous composition obtaining a film on the dipping pins; and (d) drying the film on the dipping pins so as to obtain molded capsules on the pins.
地址 Bornem BE