发明名称 |
HYDROXYPROPYL METHYL CELLULOSE HARD CAPSULES AND PROCESS OF MANUFACTURE |
摘要 |
A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells. |
申请公布号 |
US2017087092(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
US201615378856 |
申请日期 |
2016.12.14 |
申请人 |
Capsugel Belgium NV |
发明人 |
Cade Dominique Nicolas;Xiongwei David He |
分类号 |
A61K9/48;A61J3/07 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
1. A process comprising:
forming hydroxypropyl methyl cellulose hard capsules using thermogelation by: (a) providing an aqueous composition of a 2906 hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), a hydroxypropoxy content of 4.0-7.5% (w/w) and a viscosity of 3.5-6.0 cPs as a 2% weight solution in water at 20° C., wherein the aqueous composition is substantially free of gelling agent; (b) dipping heated dipping pins into the aqueous composition, wherein the aqueous composition is maintained at a temperature below a gelling temperature of the aqueous composition, (c) withdrawing the dipping pins from the aqueous composition obtaining a film on the dipping pins; and (d) drying the film on the dipping pins so as to obtain molded capsules on the pins. |
地址 |
Bornem BE |