Use of anatabine to treat inflammation and methods of synthesizing anatabine

摘要

H:/xd/Interwoven/NRPortbl/DCC/SXD/I33562121.docx-8/03/2017 Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneimine with 3-aminomethyl pyridine to form benzylhydrylidene pyridin-3-yl-methyl-amine. The benzylhydrylidene-pyridin-3-yl-methyl-amine is treated with a non-nucleophilic base and a dielectrophile, such as cis- 1,4-dichloro-2-butene, followed by acidification, then basification, to provide anatabine. 100 ______ E_ RACEMIO MIXTURE )S (S-(-)-ANATABINE Lu co40 0 10 100 200 400 600 800 1000 DOSE (pg/mL)