SYSTEMS AND METHODS FOR FITTING LD DISTRIBUTIONS AT GENOMIC SCALES

摘要

Embodiments are directed to a computer-based simulation system including an input circuit, a memory and a processor system communicatively coupled to the memory and the input circuit. The input circuit is configured to receive an input distribution. The processor system is configured to assign, for each marker of a simulated population matrix, a minor allele frequency. The processor system is further configured to assign, for each marker and each distance of the simulated population matrix, a linkage disequilibrium.

主权项

1. A computer-based simulation method comprising:
receiving, using an input circuit, an input distribution of a simulated population matrix having a first marker resolution; assigning, for each marker of the simulated population matrix, a minor allele frequency to a neighboring column of the population matrix; assigning a linkage disequilibrium for each marker and each distance of the population matrix; assimilating the minor allele frequency, the linkage disequilibrium; and outputting a genetic marker dataset for a simulated population matrix having a second markers resolution.