发明名称 |
COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS |
摘要 |
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions. |
申请公布号 |
US2017087197(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
US201615374488 |
申请日期 |
2016.12.09 |
申请人 |
The University of Tokyo |
发明人 |
Honda Kenya;Atarashi Koji;Itoh Kikuji;Tanoue Takeshi |
分类号 |
A61K35/742;G01N33/50;A61K39/08;A61K39/39;A61K39/00;C12Q1/68;A61K9/00 |
主分类号 |
A61K35/742 |
代理机构 |
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代理人 |
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主权项 |
1. A composition, comprising a purified bacterial mixture of at least two live bacterial strains belonging to Clostridium clusters IV and/or XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells, wherein the bacterial cells are isolated from a human, and wherein the composition is formulated for delivery to the intestine. |
地址 |
Tokyo JP |