Chemokine-cytokine fusion protein and application thereof

摘要

The present invention provides a fusion protein comprising the chemokine polypeptide which is a chemokine or receptor-binding domain thereof, and the cytokine polypeptide linked to said chemokine polypeptide, the cytokine polypeptide is an interleukin, a TNF-superfamily cytokine or receptor-binding domain thereof, the chemokine polypeptide and the cytokine polypeptide possess same target cells, and the fusion protein has enhanced chemokine activity comparing with said chemokine polypeptide and enhanced cytokine activity comparing with said cytokine polypeptide.