METHODS FOR ASSESSING RESPONSIVENESS TO ASTHMA TREATMENT BASED ON VNN-1 EXPRESSION AND PROMOTER METHYLATION

摘要

Provided herein are methods and kits related to use of vanin-1 (VNN1) expression for assessing responsiveness to steroid treatment in subjects with asthma and for treating subjects with asthma.

主权项

1. A method of assessing responsiveness to a steroid treatment of asthma in a subject, the method comprising:
(a) measuring a level of Vanin 1 (VNN1) expression in a biological sample obtained from a subject having asthma, suspected of having asthma, or at risk for asthma; and (b) assessing the subject's responsiveness to the steroid treatment based on the level of VNN1 expression, wherein a decreased level of VNN1 expression relative to a pre-determined value indicates that the subject is not responsive or not likely to respond to the steroid treatment, and wherein a same or elevated level of VNN1 expression relative to the pre-determined value indicates that the subject is responsive or likely to respond to the steroid treatment.