发明名称 |
PHYSICAL SELF-ORGANIZING HYDROGEL SYSTEM FOR BIOTECHNOLOGICAL APPLICATIONS |
摘要 |
A physical self-organizing hydrogel system for biotechnological applications composed of a non-covalent network on the basis of a protein-ligand interaction includes a tetrameric protein and biotin or a derivative thereof as a ligand, wherein biotin or derivative is covalently conjugated to an end of a polymer chain or a linear or multi-arm synthetic polymer of a single-or double-strand oligonucleotide and wherein the solid content in relation to the entire hydrogel is at least 3% and the conjugates are crosslinked by the tetrameric protein. A mixture ratio is a molar equivalent ratio between the protein and the number of terminal biotinylated ends of the polymer chains in the biotin-polymer conjugate of 1:2 to 1:8. The hydrogel formation occurs with controlled kinetics on the basis of protein-ligand interaction. |
申请公布号 |
US2017088814(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
US201515301038 |
申请日期 |
2015.03.27 |
申请人 |
LEIBNIZ-INSTITUTE FÜR POLYMERFORSCHUNG DRESDEN E.V. ;TECHNISCHE UNIVERSITÄT DRESDEN |
发明人 |
Thompson Michael;Wieduwild Robert;Reddavide Francesco;Tsurkan Mikhail;Andrade Helena;Wermer Carsten;Zhang Yixin |
分类号 |
C12N5/00 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
01069 Dresden DE |