发明名称 |
2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES |
摘要 |
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine compound inhibitors of beta-secretase having the structure shown in Formula (I) wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, or dementia associated with beta-amyloid. |
申请公布号 |
WO2017050978(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
WO2016EP72710 |
申请日期 |
2016.09.23 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
ROMBOUTS, Frederik, Jan, Rita;GIJSEN, Henricus, Jacobus, Maria;VAN BRANDT, Sven, Franciscus, Anna;TRABANCO-SUÁREZ, Andrés, Avelino |
分类号 |
C07D401/12;A61K31/4418;A61P25/16;A61P25/28 |
主分类号 |
C07D401/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|