POTENTIATED T-CELL MODULATOR ABLE TO MODULATE IMMUNE RESPONSE, SPECIFICALLY DESIGNED FOR THERAPEUTIC USE AS A POTENTIATING ADJUVANT IN VIRUS VACCINES

摘要

The invention relates to a leukocyte extract containing 10,000 daltons or less of polypeptides from shark spleen, and to the use thereof as an adjuvant in viral preparations used as vaccines. The invention also relates to a method for extracting and processing a dialysable leukocyte extract from selachimorpha to obtain a potentiated T-cell modulator. The invention further relates to compositions comprising a T-cell modulator and to combinations thereof with viral antigens, and provides methods for producing the compositions and formulations of the T-cell modulator as an adjuvant.