WNT INDUCED MOTILITY AND ENHANCED ENGRAFTMENT OF CELLS

摘要

The invention provides cell therapy compositions and associated methods. In particular embodiments, improved therapeutic cells and improved cell-based gene therapies for promoting cell or tissue formation, regeneration, repair or maintenance in a subject in need thereof are provided.

主权项

1. A method of increasing engraftment of a cell comprising:
(a) contacting the cell with or introducing into the cell one or more non-canonical Wnt signaling activators in vitro, for a time sufficient to increase non-canonical Wnt signaling in the cell; and (b) administering the contacted cell to a subject in need thereof;wherein the administered cell has an increased engraftment potential compared to a non-contacted cell.