USES OF DPP IV INHIBITORS

摘要

The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.

主权项

1. A method for the therapeutic treatment of a patient who has been diagnosed with a physiological functional disorder selected from among pre-diabetes, glucose intolerance, pathological fasting glucose, diabetic foot, diabetes-associated ulcer, diabetic hyperlipidaemia, diabetic dyslipidaemia, newly diagnosed type 1 diabetes, gestational diabetes, hyperglycaemia, adrenergic postprandial syndrome and heart failure, or for the therapeutic treatment of a patient with transplanted islets of Langerhans or beta cells, the method comprising administering a DPP IV inhibitor of formula (I) or of formula (II) or one of the salts thereof, wherein R1 denotes ([1,5]naphthyridin-2-yl)methyl, (quinazolin-2-yl)methyl], (quinoxalin-6-yl)methyl, (4-methyl-quinazolin-2-yl)methyl, 2-cyano-benzyl, (3-cyano-quinolin-2-yl)methyl, (3-cyano-pyridin-2-yl)methyl, (4-methyl-pyrimidin-2-yl)methyl, or (4,6-dimethyl-pyrimidin-2-yl)methyl, and R2 denotes 3-(R)-amino-piperidin-1-yl, (2-amino-2-methyl-propyl)-methylamino or (2-(S)-amino-propyl)-methylamino; optionally in combination with an active substance selected from among the other antidiabetics; active substances that lower the blood sugar level; active substances that lower the lipid level in the blood; active substances that raise the HDL level in the blood; active substances that lower blood pressure; and active substances that are indicated in the treatment of atherosclerosis or obesity.