PACKAGING SYSTEM FOR OXYGEN-SENSITIVE DRUGS

摘要

Described herein are pharmaceutical packaging systems which prevent oxidative degradation of oxygen-sensitive drugs, such systems including a primary packaging container with an oxygen permeable component, a secondary packaging with very low permeability to oxygen and an oxygen absorber.

主权项

1. A pharmaceutical product comprising:
a container filled under inert conditions with an injectable oxygen-sensitive drug, wherein the container has an oxygen permeable component, (ii) a hermetically sealed oxygen barrier blister packaging which houses the container, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOI-I) and a multilayer top web lid comprising aluminum foil or EVOH; and (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level present from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the container.