发明名称 |
RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF |
摘要 |
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an RNAi agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the RNAi agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases. |
申请公布号 |
WO2017053720(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
WO2016US53332 |
申请日期 |
2016.09.23 |
申请人 |
TARVEDA THERAPEUTICS, INC. |
发明人 |
KADIYALA, Sudhakar;WARD, Donna T. |
分类号 |
C12N15/11;C12N15/09;C12N15/113;C12N15/12 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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