发明名称 Inflammation Inhibiting Compounds
摘要 The present invention relates to the use of compounds selected from the group consisting of Lys-(D)Pro-Thr, N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and C-esters of Lys-(D)Pro-Thr; or a pharmaceutically acceptable salt of said compound for the treatment of inflammatory disorders. The invention also relates to the use of αMSH for inducing tolerance.
申请公布号 US2017087202(A1) 申请公布日期 2017.03.30
申请号 US201615379047 申请日期 2016.12.14
申请人 LUGER Thomas 发明人 LUGER Thomas
分类号 A61K38/06;A61K9/06;A61K39/00 主分类号 A61K38/06
代理机构 代理人
主权项 1. A method for treatment of an inflammatory disorder selected from the group consisting of enterocolitis, allergic reactions, food allergies, rheumatoid arthritis, multiple sclerosis, asthma, contact allergies, rhinitis, atopic dermatitis, transplant rejection, scleroderma, autoimmune diseases and inflammatory disorder of the blood vessels, comprising the step of administering to a patient in need of such treatment, a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of Lys-(D)Pro-Thr [K(D)PT] (KPT), N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and C-esters of Lys-(D)Pro-Thr; or a pharmaceutically acceptable salt of said compound, wherein said therapeutically effective amount is in the range from 20 μg/kg of body weight to 10 mg/kg of body weight.
地址 Muenster DE