COMPOSITIONS AND METHODS FOR MODIFIED DENDRIMER NANOPARTICLE VACCINE DELIVERY
摘要
Compositions and methods for modified dendrimer nanoparticle ("MDNP") delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
申请公布号
WO2017053851(A1)
申请公布日期
2017.03.30
申请号
WO2016US53520
申请日期
2016.09.23
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人
KHAN, Omar, F.;ANDERSON, Daniel, G.;LANGER, Robert, S.;CHAHAL, Jasdave, S.;PLOEGH, Hidde