ANTI-PEMBROLIZUMAB ANTIBODIES

摘要

The present invention provides antibodies and antigen-binding fragments thereof that bind to the antibody pembrolizumab (pembrolizumab). These antibodies are useful, for example, for use as positive controls in assays for detecting the presence of anti-drug antibodies in a sample, e.g., the blood of a patient who has been administered pembrolizumab.

主权项

1. An antibody or antigen-binding fragment thereof that binds pembrolizumab comprising:
(a) the CDR1, CDR2, and CDR3 of a VL domain of an immunoglobulin chain that comprises the amino acid sequence:(SEQ ID NO: 7)ELVMTQTPSSVSAAVGDTVTINCQASETVATLLAWYQQKPGQPPKLLIYGASNLESGVPSRFRGSGSGTEFTLTISGMKAEDAATYYCQYGYISTGSNTFGAGTNVEIK,(SEQ ID NO: 9)ELDMTQTPSSTSEPVGGTVTINCQASQTISSYLSWYQQKPGHPPKLLIYDASDLASGVPSRFSGSRSGTQFTLTISGVQCDDAATYYCLGVYDYRSDDGAAFGGGTELEIL,or(SEQ ID NO: 11)ELVMTQTPSSVSAAVGGTVTITCQASQSLSNLLAWYQQKPGQPPKLLIYGASNLESGVPSRFRGSGSGTDFTLTISGMKAEDAATYYCQGGHYSGLTFGNGTNVEIK;and/or(b) the CDR1, CDR2, and CDR3 of a VH domainof an immunoglobulin chain thatcomprises the aminoacid sequence:(SEQ ID NO: 8)QEQLVESGGRLVTPGTPLTLTCTASGFSLGSDFMSWVRQAPGKGLEWIGYIDPRSDIPYYASWAKGRETISKTSTTVDLKITSPTTEDTATYFCARDLNAGYFNGIFYIWGPGTLVTVSS,(SEQ ID NO: 10)QEQLVESGGRLVTPGTPLTLTCTASGFSLGSDFMSWVRQAPGKGLEWIGYIDPRSDIPYYASWAKGRETISKTSTTVDLKITSPTTEDTATYFCARDLNAGYFNGIFYIWGPGTLVTVSS,or(SEQ ID NO: 12)QSLEESGGRLVTPGTPLTLTCTVSGFSLSTNDMNWVRQAPGKGLEWIGVIYSDDTPDYATWAKGRETISRTSTTVDLKITSPTTEDTATYFCARGHYDSAVYAYALNIWGPGTLVTVSS.