COMPOSITIONS AND METHODS FOR ACTIVE SURVEILLANCE OF PROSTATE CANCER

摘要

Aspects of the disclosure relate to improved methods and systems for active surveillance of subject having non-aggressive prostate cancer.

主权项

1. A method of evaluating a subject previously diagnosed as having non-aggressive prostate cancer, the method comprising:
i) subjecting a blood sample of the subject to one or more immunoassays that measure levels of one or more kallikrein markers selected from: free prostate specific antigen (fPSA), intact prostate specific antigen (iPSA), total prostate specific antigen (tPSA) and human kallikrein 2 (hK2); and ii) determining the probability that a prostate tissue biopsy obtained from the subject would contain detectable aggressive prostate cancer by weighting the measured one or more kallikrein marker levels and at least one clinical factor; wherein the at least one clinical factor is selected from a prior negative biopsy or the subject's age.