USES OF MITO-OB TRANSGENIC MICE

摘要

The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.

主权项

1. A method of determining if a compound of interest reduces severity of non-alcoholic steatohepatitis and/or hepatocellular carcinoma comprising:
growing a transgenic mouse overexpressing the mitochondrial protein prohibitin (PHB) to approximately at least 3 months of age, wherein the PHB gene is operably linked to the adipocyte protein 2 (aP2) promoter; administering the compound of interest to the transgenic mouse; and determining if the compound of interest delays onset or reduces severity of non-alcoholic steatohepatitis and/or hepatocellular carcinoma.