发明名称 |
A CONTINUOUS FLOW PROCESS FOR THE PREPARATION OF INGENOL-3-MEBUTATE |
摘要 |
Disclosed is a continuous process for the preparation of ingenol-3-mebutate by reaction, in solution, of ingenol or ingenol anion and angelic anhydride or an equivalent angelylating agent. The continuous flow process is preferably performed in the presence of a base such as lithium hexamethyl disilazane (LiHMDS) and/or an activating agent such as dicyclohexylcarbodiimide (DCC). Also disclosed is a process for recycling the other reaction products obtained in the continuous process for preparation of ingenol-3-mebutate for formation of ingenol, which can then be recycled to form ingenol-3-mebutate. |
申请公布号 |
EP3145903(A1) |
申请公布日期 |
2017.03.29 |
申请号 |
EP20150795769 |
申请日期 |
2015.04.10 |
申请人 |
Alphora Research Inc. |
发明人 |
JORDAN, Robert W.;DIXON, Craig;GORIN, Boris |
分类号 |
C07C67/08;C07C67/48;C07C69/533 |
主分类号 |
C07C67/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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