PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS

摘要

The present invention relates to novel compounds which are highly selective inhibitors of diacylglycerol lipase ± and ². These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by increased 2-arachidonoylglycerol levels. Diacylglycerol lipase-± (alternative name: Sn1-specific diacylglycerol hydrolase a; DAGL-±) and -² are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The inventive ompounds are in particular suitable for the treatment of neurodegenerative diseases, inflammatory diseases, drug abuse and impaired energy balance, such as obesity.