| 发明名称 | Biocatalytic process for preparing eslicarbazepine and analogs thereof | ||
| 摘要 | The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof. | ||
| 申请公布号 | US9605290(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201615150686 | 申请日期 | 2016.05.10 |
| 申请人 | Codexis, Inc. | 发明人 | Gohel Anupam;Smith Derek J.;Wong Brian;Sukumaran Joly;Yeo Wan Lin;Collier Steven J.;Novick Scott |
| 分类号 | C12N9/04;C12N9/02;C12N15/63;C07H21/04;C12P17/10;C07D223/22;C07D223/28;C07D453/02;C12P41/00 | 主分类号 | C12N9/04 |
| 代理机构 | Codexis, Inc. | 代理人 | Codexis, Inc. |
| 主权项 | 1. A non-naturally occurring polynucleotide encoding a polypeptide capable of converting compound (2c) to compound (1c) in enantiomeric excess in presence of NADPH, the ketoreductase polypeptide comprising an amino acid sequence that has at least 80% sequence identity to SEQ ID NO:10 and has at least the following features: X80 is T; X96 is V or R; X145 is L; X153 is T; X190 is P; X196 is L or M; and X226 is V. | ||
| 地址 | Redwood City CA US | ||