Dry powder formulations of dNase I

摘要

DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder inhalation devices and systems for the therapeutic use thereof are provided.

主权项

1. An inhalable dry powder formulation comprising a human DNase I protein and particles of a physiologically acceptable pharmacologically-inert solid carrier, wherein said human DNase I protein is a plant expressed recombinant human DNase I protein comprising an N-terminal Glycine residue at position 1 of said human DNase I protein.