| 发明名称 | Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore | ||
| 摘要 | Provided herein are fluoropyrimidine-modified RNA aptamers capable of binding CCR5. The compositions and methods provided herein are, inter alia, useful for the delivery of anti-viral drugs (e.g., siRNAs) and preventing HIV entry into a target cell. | ||
| 申请公布号 | US9605266(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201514801710 | 申请日期 | 2015.07.16 |
| 申请人 | CITY OF HOPE;THE SCRIPPS RESEARCH INSTITUTE | 发明人 | Rossi John;Zhou Jiehua;Weinberg Marc;Morris Kevin |
| 分类号 | C12N15/11;A61K48/00;C07H21/04;C12N15/115 | 主分类号 | C12N15/11 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. |
| 主权项 | 1. A chimeric construct comprising an aptamer and antiviral siRNA, optionally linked by a suitable linker, wherein said aptamer has at least 80% sequence identity with G-3:(SEQ ID NO: 1)5′-GGG AGG ACG AUG CGG GCC UUC GUU UGU UUC GUC CACAGA CGA CUC GCC CGA-3′. | ||
| 地址 | Duarte CA US | ||