| 发明名称 | Chimeric antibacterial polypeptides | ||
| 摘要 | Provided herein are antibacterial compositions and methods of making and using the compositions. | ||
| 申请公布号 | US9605250(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201214111531 | 申请日期 | 2012.04.12 |
| 申请人 | Gangagen, Inc. | 发明人 | Appaiah Chemira B.;Padmanabhan Sriram;Saravanan R. Sanjeev;Sriram Bharathi |
| 分类号 | A61K38/43;C12N9/24;C12N9/36;C12N1/06;C12N15/62;C07K14/47;C12N9/48;C07K14/005;A61K38/00 | 主分类号 | A61K38/43 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A chimeric polypeptide comprising a muralytic domain (MD) from a virion-associated muralytic enzyme, wherein the MD comprises a sequence at least 90% identical to amino acids 683-898 of SEQ ID NO:2 and is capable of lysing chloroform-treated Pseudomonas aeruginosa bacteria and a membrane traversing domain (MTD) segment, wherein the segment comprises a sequence at least 80% identical to amino acids 16-39 of SEQ ID NO:4 and is capable of traversing the outer membrane of Pseudomonas aeruginosa bacteria. | ||
| 地址 | Newark CA US | ||