发明名称 |
Inhibitor of τ protein phosphorylation |
摘要 |
8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid has a protein tyrosine phosphatase 1B (PTP1B) inhibitory action, an Akt activating action, a GSK-3β phosphorylation promoting action, and a suppressive action on τ protein phosphorylation induced by Aβ1-42, and is useful as a therapeutic drug for Alzheimer-type dementia, an antidepressant and/or an anti-aging drug. |
申请公布号 |
US9603821(B2) |
申请公布日期 |
2017.03.28 |
申请号 |
US201414769707 |
申请日期 |
2014.02.21 |
申请人 |
Nishizaki Bioinformation Research Institute |
发明人 |
Nishizaki Tomoyuki;Tanaka Akito |
分类号 |
A61K31/20 |
主分类号 |
A61K31/20 |
代理机构 |
Leydig, Voit & Mayer, Ltd. |
代理人 |
Leydig, Voit & Mayer, Ltd. |
主权项 |
1. A method of activating Akt comprising administering an effective amount of DCP-LA to a patient in need thereof, wherein the DCP-LA activates PKCε, and the PKCε directly activates Akt in the patient. |
地址 |
Kobe JP |