Polymer adhesives comprising a low boiling point biocompatible solvent, high molecular weight multi-arm star cyanoacrylate-telechelic polyisobutylene and 2-octyl cyanoacrylate

摘要

The present invention is directed to a substantially homogeneous miscible liquid adhesive composition comprising a relatively high number average molecular weight (Mn=6,000-10,000 g/mole) multi-arm star polymer having polyisobutylene chains terminated with cyanoacrylate groups (High-Ø(PIB-CA)3); 2-octyl cyanoacrylate (Oct-CA); and a low boiling point biocompatible solvent having a boiling point of not more than 37° C. When this adhesive composition contacted with living tissue and reacted with a nucleophile, such as water or an initiator, the biocompatible solvent will evaporate and the High-Ø(PIB-CA)3 and Oct-CA will co-polymerize in-situ to form a poly(2-octyl cyanoacrylate)-polyisobutylene co-network suitable for any of a number of biomedical applications, from wound closure and healing of skin tissue, to sealant for surgical cuts.

主权项

1. A liquid adhesive composition useful for wound closure and skin protection comprising:
a multi-arm star polymer comprising polyisobutylene chains terminated with cyanoacrylate groups and having a number average molecular weight of from about 6,000 g/mole to about 10,000 g/mole; 2-octyl cyanoacrylate; and a low boiling point biocompatible solvent having a boiling point of not more than 37° C.; wherein both said multi-arm star polymer and said 2-octyl cyanoacrylate are miscible in said low boiling point biocompatible solvent.