Deep brain electrode placement and stimulation based on brown adipose tissue temperature

摘要

Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a deep brain stimulating electrode in a target region of the brain of a patient, a temperature of brown adipose tissue (BAT) may be monitored, e.g., via a supraclavicular temperature sensor implanted in the patient, and used to identify an optimal location of electrode stimulation which causes an increase in BAT temperature. Additionally, BAT temperature measurements may be used to provide regulated closed-loop control to increase efficiency of DBS while reducing energy consumption of the pulse generator. Further, core temperature measurements may be obtained from the electrode in the brain and used to adjust DBS.

主权项

1. A computerized method for placement of a deep brain stimulation electrode and regulation of deep brain stimulation in a patient, comprising:
delivering deep brain stimulation via the deep brain stimulation electrode directly to a first location in a target region of the hypothalamus of the patient in response to an initial insertion of the electrode to the target region by positioning the deep brain stimulation electrode in the first location in the target region of the hypothalamus; receiving temperature measurements from a brown adipose tissue temperature sensor; in response to an increasing brown adipose tissue temperature condition, outputting an indication to secure the electrode for delivery of deep brain stimulation directly to the first location; and in response to a non-increasing brown adipose tissue temperature condition, outputting an indication to adjust the electrode by positioning the deep brain stimulation electrode in an adjusted location in the target region of the hypothalamus until an increasing brown adipose tissue temperature condition occurs during delivery of deep brain stimulation directly to the adjusted location in the target region, and then outputting an indication to secure the electrode for delivery of deep brain stimulation directly to the adjusted location.