Prostaglandin conjugates and derivatives for treating glaucoma and ocular hypertension

摘要

Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma and elevated intraocular pressure are disclosed. Such compositions comprise an effective amount of prostaglandin conjugates or derivatives of the present invention.

主权项

1. An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure, comprising an effective amount of a compound (I) of the following formula: in which A is selected from the group consisting of: where: n is 1-6; R1, R2, R3 independently=OH or O—NO2; R4, R5 independently=H, alkyl, or heteroalkyl; or R4 and R5 can combine to form cyclic alkyl or cyclic heteroalkyl; and R6 independently=H, NO2, organic nitrate, organic nitrite, metal —NO complex, sodium nitroprusside (SNP), dinitrosyl iron thiol complex (DNICs), N-nitrosamine, N-hydroxy-N-nitrosamine, N-nitrosimine, nitrosimine, C-nitroso, diazetine dioxide, furoxan, benzofuroxan, oxatriazole-5-imine, sydnonimine, oxime, hydroxylamine, N-hydroxyguanidine, or hydroxyurea; and a pharmaceutically acceptable vehicle therefor.