| 主权项 |
1. A method of treating a fungal infection in a subject comprising:
administering to the subject a therapeutically effective amount of a disulfide thioredoxin protein inhibitor to treat the fungal infection in the subject, the thioredoxin protein inhibitor comprising a small molecule having a molecular weight of less than about 350 g/mole, the thioredoxin inhibitor including an asymmetrical or symmetrical disulfide having the formula R1—S—S—Y—S—S—R2, wherein R1, R2, and Y are each independently selected from the group consisting of a substituted or unsubstituted alkyl, arylalkyl, imidazole, thiadiazole, thiazole, benzimidazole, purine, phenyl, benzyl, phenylethyl, pyridine, pyrimidine, benzoxazole, benzthiazole, cycloalkyl, hydroxylalkyl, carboxyalkyl, haloalkyl, catopril, and cycloalkanone; and pharmaceutically acceptable salts thereof. |
