Methods of treating inflammatory and autoimmune diseases and disorders using nanolipogels

摘要

Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. The nanolipogel includes a lipid bilayer surrounding a hydrogel core, which may optionally include a host molecule, for example, an absorbent such as a cyclodextrin or ion-exchange resin. In preferred embodiments at least one of active agents is an immunosuppressant.

主权项

1. A method of treating a subject with an inflammatory, allergic, or autoimmune disease or disorder comprising administering to the subject a composition comprising an effective amount of nanolipogels comprising
a polymeric matrix formed of crosslinked polymer, amphiphilic polymer, block copolymer, or tri-block copolymer having dispersed therein or covalently bound thereto one or more host molecules which reversibly complex with or bind an agent, wherein the host molecules are selected from the group consisting of one or more polysaccharides, cryptands, cryptophanes, cavitands, crown ethers, dendrimers, catenanes, carcerands, spherands, carbon nanotubes and fullerenes, for controlled release of at least one therapeutic, diagnostic or prophylactic agent, and a lipid shell; wherein one or more active agents for reducing, decreasing, or alleviating one or more symptoms of the inflammatory, allergic, or autoimmune disease or disorder are reversibly complexed or bound to the host molecules, dispersed within the polymeric matrix, dispersed in or bound to the lipid shell, or combinations thereof.