发明名称 |
Chimeric receptors with 4-1BB stimulatory signaling domain |
摘要 |
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. |
申请公布号 |
US9605049(B2) |
申请公布日期 |
2017.03.28 |
申请号 |
US201414301122 |
申请日期 |
2014.06.10 |
申请人 |
St. Jude Children's Research Hospital, Inc. |
发明人 |
Campana Dario;Imai Chihaya |
分类号 |
C07K14/705;C07K16/28;C12N5/0783;A61K39/395;C07K14/47;C07K14/725 |
主分类号 |
C07K14/705 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A polynucleotide encoding a chimeric receptor comprising: (a) an extracellular ligand-binding domain comprising an anti-CD19 single chain variable fragment (scFv) domain; (b) a transmembrane domain of CD8α; and (c) a cytoplasmic domain comprising a human 4-1BB signaling domain and a CD3ζ signaling domain. |
地址 |
Memphis TN US |