Urea hydantoin derivatives as formyl peptide modulators

摘要

The present invention relates to urea hydantoin compounds, processes for preparing them, pharmaceutical compositions containing them, and their use as pharmaceuticals as modulators of the FPR2 receptor, and to methods of treating inflammatory diseases or conditions in a subject in need thereof by administering the compound(s) or pharmaceutical composition to the subject.

主权项

1. A compound represented by Formula I: wherein: R1 is optionally substituted C1-8 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C6-C10 aryl, or optionally substituted heterocycle; R2 is H, or optionally substituted C1-8alkyl; R3 is NR5; n is 1 or 2; m is 1 or 2; R4 is —C(O)R6, R5 is H or optionally substituted C1-8alkyl; R6 is —OC1-8alkyl or OH; R7 is H or optionally substituted C1-8alkyl; R8 is H or optionally substituted C1-8alkyl; R9 is H or optionally substituted C1-8alkyl; R10 is H or optionally substituted C1-8alkyl; R11 is H or optionally substituted C1-8alkyl; R12 is H, —OH, NR14R15 or optionally substituted C1-8alkyl; R13 is H or optionally substituted C1-8alkyl; R14 is H or optionally substituted C1-8alkyl; and R15 is H or optionally substituted C1-8alkyl;or an enantiomer, diastereomer or tautomer thereof;or a zwitterion or pharmaceutically acceptable salt of the foregoing.