| 主权项 |
1. A method of producing a compound represented by Formula (4-8): wherein; R4 and R5 are independently selected from hydrogen, methyl, ethyl, allyl, propyl or isopropyl; and R6 is a) R11, where R11 is selected from:
1) Hydrogen;2) Deuterium;3) C1-C8 alkyl;4) Substituted C1-C8 alkyl;5) C2-C8 alkenyl;6) Substituted C2-C8 alkenyl;7) C2-C8 alkynyl;8) Substituted C2-C8 alkynyl;9) C3-C12 cycloalkyl;10) Substituted C3-C12 cycloalkyl;11) Aryl;12) Substituted aryl;13) Heterocycloalkyl;14) Substituted heterocycloalkyl;15) Heteroaryl; and16) Substituted heteroaryl; b) —C(O)OR11, where R11 is as previously defined; c) —C(O) R11, where R11 is as previously defined; d) —C(O)OCH2-T-R12, where T is —O— or —S— and R12 is selected from:
a. C1-C8 alkyl;b. Substituted C1-C8 alkyl;c. C2-C8 alkenyl;d. Substituted C2-C8 alkenyl;e. C2-C8 alkynyl;f. Substituted C2-C8 alkynyl;g. C3-C12 cycloalkyl;h. Substituted C3-C12 cycloalkyl;i. Aryl;j. Substituted aryl;k. Heterocycloalkyl;l. Substituted heterocycloalkyl;m. Heteroaryl; orn. Substituted heteroaryl; e) —C(O)N(R13)(R14), where R13 and R14 are independently selected from R11 and R11 is as previously defined or R13 and R14 , together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl; f) —C(O)SR11, R11 is as previously defined; g) —C(S)O R11,where R11 is as previously defined; h) —C(O)OCH2OC(O) R12, where R12 is as previously defined; i) —C(S)S R11, where R11 is as previously defined; j) R15,where R15 is selected from:
a. —M—R11, where R11 is as previously defined and M is selected from:
i. C1-C8 alkyl;ii. Substituted C1-C8 alkyl;iii. C2-C8 alkenyl;iv. Substituted C2-C8 alkenyl;v. C2-C8 alkynyl;vi. Substituted C2-C8 alkynyl;vii. C3-C12 cycloalkyl; andviii. Substituted C3-C12 cycloalkyl;b. —M—NR16R11, where R16 is R11 or R16 and R11 together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocycloalkyl, M is as previously defined;c. —M—S(O)mR11, where m =0, 1,or 2; M and R11 are as previously defined;d. —M—OR11, where M and R11 are as previously defined;e. —M—C(O) R11, where M and R11 are as previously defined;f. —M—OC(O) R12, where M and R12 are as previously defined;g. —M—OC(O)O R12, where M and R12 are as previously defined;h. —M—NR17C(O) R12, where R17 is R11, M and R12 are as previously defined;i. —MNR17C(O)O R12, where R17, M and R12 are as previously defined;j. —M—C(O)NR16 R11, where R16, M and R11 are as previously defined;k. —M—C(O)N(R16)—OR11, where R16, M and R11 are as previously defined;l. —M—OC(O)NR16 R11, where R16, M and R11 are as previously defined;m. —M—NR17C(O)NR16 R11, where M, R11, R16 are as previously defined or R16 and R11 together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocycloalkyl;n. —M—C(S)S R11, where M and R11 are as previously defined;o. —M—OC(S)S R12, where M and R12 are as previously defined;p. —M—NR17C(O)S R12, where M, R17 and R12 are as previously defined;q. —M—SC(O)NR16 R11, where M, R11 and R16 are as previously defined or R16 and R11 together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocycloalkyl;r. —M—CH═N—O R11, where M and R11 are as previously defined;s. —M—CH═N—NR16 R11 R16 are as previously defined or R16 and R11 together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocycloalkyl; said method comprising the steps of: (1) reacting a compound of Formula 1-3, with a reducing agent in a protic solvent; (2) reacting the product of step (1) with Fmoc-Cl in an aprotic solvent in the presence of an organic base to produce a compound of Formula (4-1), (3) contacting the compound of Formula (4-1) with an acid in a protic solvent; (4) reacting the product of step (3) with acetic anhydride in an aprotic solvent in the presence of a base, thereby producing a compound of Formula (4-2), (5) reacting the compound of Formula (4-2) with sodium methoxide in methanol to produce a compound of Formula (4-3). (6) reacting the compound of Formula (4-3) with a compound of Formula (4-4), in an aprotic solvent in the presence of a coupling reagent and a base to produce a compound of Formula (4-5), (7) reacting the compound of Formula (4-5) with an acid to produce a compound of Formula (4-6), (8) reacting the compound of Formula (4-6) with alkali in a protic solvent to produce a compound of Formula (4-7), (9) reacting the compound of Formula (4-7) with a coupling reagent and a base in an aprotic solvent, thereby producing the compound of Formula (4-8). |
