| 发明名称 | Rapid selection method for HIV gp-120 variants | ||
| 摘要 | The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient. | ||
| 申请公布号 | US9605030(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201214000924 | 申请日期 | 2012.02.24 |
| 申请人 | LABORATORIOS DEL DR. ESTEVE, S.A.;FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA | 发明人 | Yuste Herranz María Eloísa;Sánchez Merino Víctor;Ferreira Carolina |
| 分类号 | C07K14/16;G01N33/68;C07K14/005;C12N15/10;C07K16/10;G01N33/569;A61K39/00 | 主分类号 | C07K14/16 |
| 代理机构 | Jenkins, Wilson, Taylor & Hunt, P.A. | 代理人 | Jenkins, Wilson, Taylor & Hunt, P.A. |
| 主权项 | 1. A polypeptide capable of eliciting neutralizing antibodies against a virus, wherein the polypeptide comprises a variant HIV-1 gp120 or an immunogenic fragment thereof, and further wherein the variant gp120 or the immunogenic fragment thereof is selected from the group consisting of a polypeptide which comprises at least one mutation at a position selected from the group consisting of positions 88, 131, 132, 138, 160, 191, 203, 225, 479, 507, 604 and 647 with respect to the numbering of SEQ ID NO:2, wherein the polypeptide or the immunogenic fragment thereof comprises a sequence selected from the group consisting of SEQ ID NOs:4, 17, 19-29, and 31. | ||
| 地址 | Barcelona ES | ||