Two-dimensional separation and imaging technique for the rapid analysis of biological samples

摘要

A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionizing and mass analyzing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. The sample is deposited onto and separated on the target surface by mechanical, hydrodynamic and/or aerodynamic means.

主权项

1. A method of ion mapping comprising:
depositing a sample onto a metallic target surface;separating said sample on said target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension; and
ionising and mass analysing multiple separate regions of said sample so as to generate an ion map of at least a portion of said sample deposited upon said target surface;wherein said sample is deposited onto and separated on said target surface by mechanical, hydrodynamic and/or aerodynamic means.