| 发明名称 | Methods, compositions, and kits for treating pain and pruritis | ||
| 摘要 | The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels. | ||
| 申请公布号 | US9603817(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201414496629 | 申请日期 | 2014.09.25 |
| 申请人 | President and Fellows of Harvard College;The General Hospital Corporation | 发明人 | Bean Bruce P.;Woolf Clifford J. |
| 分类号 | A61K31/14;A61K31/167;A61K31/085;A61K31/165;A61K45/06;A61K9/00 | 主分类号 | A61K31/14 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A method for treating itch in a patient, said method comprising administering to said patient a composition comprising a compound capable of inhibiting one or more voltage-gated ion channels present in pruriceptors when applied to the internal face of said channels but does not substantially inhibit said channels when applied to the external face of said channels, wherein said compound is capable of entering pruriceptors through a channel-forming receptor when said receptor is activated and inhibiting said one or more voltage-gated ion channels present in said pruriceptors. | ||
| 地址 | Cambridge MA US | ||