TARGETING OF CHONDROITIN SULFATE GLYCANS

摘要

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

主权项

1. A method for the treatment of any indication associated with expression, such as inappropriate expression of CSA, such as in cancer, arthritis, arthrosis, multiple sclerosis, pathological conditions caused by neural damage, conditions of the cartilage and scar tissue, such as in rheumatism, cartilage repair or wound healing, or in psoriasis; the method comprising administering a therapeutically or prophylactically effective amount of a VAR2CSA polypeptide, or a conjugate or fusion protein comprising a VAR2CSA polypeptide and a therapeutic or diagnostic effector moiety, such as a cytotoxic moiety, fluorescent label, and/or a radiolabel; to a subject in need thereof.