Methods of Diagnosing and Treating Autism

摘要

Methods for diagnosing and treating autism spectral disorders are encompassed. In one embodiment, a patient is diagnosed as having autism spectral disorder if at least one CNV in an mGluR network gene is found in a patient sample. Patients with at least one mGluR network gene CNV are effectively treated with (+)-5-oxo-Dprolinepiperidinamide monohydrate (NS-105).

主权项

1. A method of treating autism spectrum disorder (ASD) in a human patient comprising administering a therapeutically effective amount of fasoracetam (NS-105) to the patient, wherein the patient has at least one CNV in a gene selected from the group consisting of ACAT1, ACAT2, ACP1, ACTR2, ADCY1, ADD1, ADRA2C, ADRBK1, AGAP2, ALDOA, APTX, ARHGAP24, ARL15, BDKRB1, BDKRB2, Clorf116, C4orf3, C7orf25, CA8, CACNA1B, CALB2, CALM1, CAMK2B, CHP, CHRM3, CNPY2, CNR1, COPB2, DCN, DHCR7, DISCI, DSTN, ECHS1, EGFR, ERBB2, ERP44, F2RL2, FKBP3, FURIN, GLP1R, GLP2R, GNA15, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNB2L1, GRB2, GRB7, GRIK1, GRM1, GRM3, GRM5, GRM7, GRM8, GSN, HNRNPA3, HOMER1, HOMERS, HTT, IMPDH2, IQGAP2, ITGB7, ITPR1, LAMA4, LRP2BP, LYAR, LYN, MAP4, MAPK1, MTHFD1, MTNR1A, MX1, MYO6, NAA15, NCK1, NPY2R, PCBP1, PCBP3, PCDHA4, PDE1C, PICK1, PIK3CA, PLA2G7, PLCB1, PRDX1, PRKCA, PRPSAP1, PSMC1, PSMD1, PSMD13, PSME1, PXN, RAB2A, RANBP1, RAP2A, RCC1, RGS12, RPA2, RPN2, RUVBL2, RYR2, S100A6, SACS, SDC3, SERPINB9, SLC6A3, SNRPB2, SRC, STRAP, STX12, SYK, TCP1, TEAD3, TFAM, TJP1, TRAF2, TUBA1A, TUBA3C, TXN, UBQLN4, VHL, and YWHAQ, thereby treating ASD in the patient.