| 发明名称 |
ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME |
| 摘要 |
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described. |
| 申请公布号 |
US2017081395(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
US201615147265 |
申请日期 |
2016.05.05 |
| 申请人 |
Teva Pharmaceuticals International GmbH |
发明人 |
Zeller Joerg;Poulsen Kristian T.;Abdiche Yasmina Noubia;Pons Jaume;Collier Sierra Jones;Rosenthal Arnon |
| 分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for reducing incidence of or treating cluster headache in an individual, comprising administering to the individual an effective amount of an anti-CGRP antagonist antibody, wherein the anti-CGRP antagonist antibody is a human or humanized antibody that blocks or decreases cyclic adenosine monophosphate (cAMP) activation in cells. |
| 地址 |
Jona CH |
